I haven’t tried this personally (yet) but there is a nice how-to over at LaptopMag.com that details how to install Skype 2.0 on the Asus Eee PC and make video calls with it.
While we have Skype 2.0 support on the Zonbu, the Zonbu hardware currently lacks any built-in camera. More annoyingly, the Logitech family of Quickcams (one of the most popular) does not currently work either. As I’ve noted for months, this is a key area Zonbu needs to progress rapidly.
You can read the LaptopMag.com post here: http://www.laptopmag.com/features/Skype-with-Your-Webcam-on-the-Eee-PC.htm